Is Automation Required to do Experimental Design?

Does DoE require expensive automation to implement? Absolutely not! Expensive automated equipment is not a prerequisite to using experimental design, some tactics for design success are discussed below.

Finding the balance of information and cost

We recently worked with one of our DoE coaching clients to determine the best experimental approach for a project with 2 main challenges: a) several categorical factors and b) expensive analysis (approx. $1000 a sample!). Normally (a) results in high experiment numbers which doesn't work well for (b)!

What To Expect When Working With A Consultant

DoE and other enabling technologies

How do DoE, HTE, Bayesian Optimisation and Self-optimising reactions compare, and is there a best option for process development?

What is Quality by Design?

All products are made by following a process, a recipe if you like...

DoE and Formulation Chemistry

Can I use design of experiments to improve my formulation?

Virtual Training DoE Course

With the current restrictions on travel and face to face training, we have moved our training online. In collaboration with Scientific Update we ran our popular DoE course from the 5th-8th October 2020 and the QbD course from the 9th – 13th November 2020.

Reducing experiment numbers

DoE is a very powerful tool to efficiently look at the cause and effect relationship between factors such as temperature and concentration, and responses such as conversion and impurity formation. DoE looks at each factor at 2 or more levels.

Risk assessments in the Quality by Design Process

There is no doubt if you are working in the pharmaceutical industry you should be employing the Quality by Design principles to achieve robust processes and consistently high quality products. Successful risk assessment is a fundamental aspect of QbD, however, risk analysis is a subjective process and is open to human bias and inaccuracy.

How to quickly change from batch to continuous processing

Adopting a new technology may sound daunting but it doesn’t have to be complicated. If you have been thinking about moving to continuous processing for a while but don’t know where to start, employing experimental design is a systematic way to quickly determine the optimum operating conditions for a flow process.